EDMONDSON H A
Calif Med. 1952 Sep;77(3):176-9.
The physiological phenomena accompanying pancreatic disease in adults are related to the local and generalized reaction of the body to the blockage and/or leakage of the three enzymes-amylase, lipase and trypsin. The measurements of amylase and lipase in the serum are the most reliable criteria in the diagnosis of acute disease. Related changes may include hypocalcemia, hypopotassemia, hyperlipemia, hyperglycemia and decreased renal function. In chronic pancreatitis, there is less fluctuation in the amounts of the enzymes in the blood. The presence of diabetes mellitus, demonstration of calculi by x-ray, and examination of the stools for excess fat and meat fibers are more important diagnostic guides. In cancer of the pancreas, function tests using secretin stimulation of the gland followed by an examination of the external secretion or determination of the serum amylase have been used with some success.
成人胰腺疾病伴随的生理现象与身体对淀粉酶、脂肪酶和胰蛋白酶这三种酶的阻塞和/或渗漏的局部及全身反应有关。血清淀粉酶和脂肪酶的测定是诊断急性疾病最可靠的标准。相关变化可能包括低钙血症、低钾血症、高脂血症、高血糖症及肾功能减退。在慢性胰腺炎中，血液中酶的含量波动较小。糖尿病的存在、通过X射线显示结石以及检查粪便中是否有过多脂肪和肉质纤维是更重要的诊断依据。在胰腺癌中，使用促胰液素刺激胰腺后进行外分泌检查或血清淀粉酶测定的功能测试已取得了一定成功。
