Sosnowska D, Dzierzbicka K, Myśliwski A, Kołodziejczyk A M
Katedra i Zakład Histologii Akademii Medycznej, Gdańsku.
Postepy Hig Med Dosw. 1992;46(5):521-30.
This paper presents a review of studies on the metabolism, pharmacological and clinical properties of a new synthetic muramyl dipeptide derivative N2-/(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl/-N6-stearoyl-L-lysine(MD P- Lys(L18), muroctasin). Due to its effect on the number of peripheral blood leukocytes this compound is expected to be a useful drug for the treatment of leukopenia induced by cancer chemotherapy or radiation therapy.
本文综述了一种新型合成的胞壁酰二肽衍生物N2-/(N-乙酰胞壁酰)-L-丙氨酰-D-异谷氨酰胺基/-N6-硬脂酰-L-赖氨酸(MD P-Lys(L18)，莫罗他辛)的代谢、药理及临床特性。由于其对外周血白细胞数量的影响，预计该化合物将成为治疗癌症化疗或放疗引起的白细胞减少症的有效药物。
