Hiraoka A, Masaoka T, Satoh T, Ota K, Oyama A, Horiuchi A, Hasegawa H, Nagai K, Kosaki M, Kanemaru A
Fifth Department of Internal Medicine, Center for Adult Diseases, Osaka, Japan.
Arzneimittelforschung. 1988 Oct;38(10):1499-501.
A randomized crossover trial was performed in 20 patients receiving chemotherapy for malignant lymphoma. N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin) at a dose of 200 micrograms was subcutaneously administered after one of two cycles of the same protocol. The administration was started on day 4 after the start of chemotherapy and continued for 10 days. The mean length from the start of chemotherapy to nadir of white blood cell (WBC) was not significantly different between the control and muroctasin cycles. The mean WBC and neutrophil counts at nadir of the control cycle were significantly lower than those at the same point of muroctasin cycle, respectively. A positive effect of muroctasin cycle, defined as WBC count at nadir being increased by 1,000/mm3, WBC count being increased by 1,000/mm3 on two points examined after nadir, or faster reach to nadir and faster recovery to normal range of WBC than in the control cycle, was observed in 7 (35%) of 20 patients. On the other hand, only one (5%) patient showed a superiority of the control cycle over the muroctasin cycle. Toxic effects of muroctasin were observed in 34.8% of patients, but were tolerable for most patients. These results show that muroctasin has a clinical efficacy in the restoration of leukopenia after chemotherapy.
对20例接受恶性淋巴瘤化疗的患者进行了一项随机交叉试验。在相同方案的两个周期中的一个周期后，皮下注射剂量为200微克的N2-[(N-乙酰胞壁酰)-L-丙氨酰-D-异谷氨酰胺基]-N6-硬脂酰-L-赖氨酸（MDP-Lys(L18)，mur octasin）。给药在化疗开始后第4天开始，持续10天。从化疗开始到白细胞（WBC）最低点的平均时长在对照组和mur octasin周期之间无显著差异。对照组周期最低点时的平均WBC和中性粒细胞计数分别显著低于mur octasin周期相同时间点的计数。在20例患者中有7例（35%）观察到mur octasin周期的积极效果，定义为最低点时WBC计数增加1000/mm³、最低点后两个检测点WBC计数增加1000/mm³，或比对照组周期更快达到最低点并更快恢复到WBC正常范围。另一方面，只有1例（5%）患者显示对照组周期优于mur octasin周期。34.8%的患者观察到mur octasin的毒性作用，但大多数患者可以耐受。这些结果表明，mur octasin在化疗后白细胞减少的恢复方面具有临床疗效。
