Klimowicz A
Klinika Dermatologiczna Pomorskiej Akademii Medycznej, Szczecinie.
Postepy Hig Med Dosw. 1992;46(5):537-54.
Pharmacokinetic properties of sulfametrole, sulfamoxole, sulphamerazine, sulphadiazine, sulphamethoxazole and sulfamethopyrazine, i.e. the sulphonamides administered in combination with trimethoprim have been compared. From the pharmacokinetic point of view sulphadiazine seems to be the most optimal sulphonamide to apply jointly with trimethoprim. Some of long-acting sulphonamides like sulfamethopyrazine and sulfadimethoxine, used as components of above mentioned combinations, possess comparable clinical efficacy in spite of differences of their and trimethoprim half-lives.
已对磺胺甲氧嗪、磺胺恶唑、磺胺甲基嘧啶、磺胺嘧啶、磺胺甲恶唑和磺胺甲吡嗪的药代动力学特性进行了比较，这些磺胺类药物与甲氧苄啶联合使用。从药代动力学角度来看，磺胺嘧啶似乎是与甲氧苄啶联合使用的最理想的磺胺类药物。一些长效磺胺类药物，如磺胺甲吡嗪和磺胺二甲氧嘧啶，作为上述组合的成分使用时，尽管它们与甲氧苄啶的半衰期存在差异，但仍具有相当的临床疗效。
