[Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy].

Pharmacokinetics of the sulphamerazine/trimethoprim-combination Berlocombin-200 was calculated by an one-compartment-model following therapeutic administration in pregnant women and compared with a control group. Distribution parameters are significantly changed, but elimination half-lifes of both the sulphonamide and trimethoprim are not influenced by repeated administration during pregnancy. There are no consequences concerning the dosage of Berlocombin in bacterial infections during pregnancy.