Guo J
Cardiovascular Institute, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1992 Oct;14(5):378-81.
The plasma renin activity (RA), the concentration and the ratio of angiotensin (AI) conversion into angiotensin II (AII), and arginine vasopressin (AVP) level were observed in Wistar rats with pulmonary hypertension (PH) induced by extracardiac left-to-right shunting (LRS), hypobaric hypoxia (HH) and shunting plus HH (SHH). In comparison with normal control rats, RA in LRS and SHH rats showed an increasing trend, although no statistical significance appeared (P > 0.05). No change occurred in HH rats. The concentration and ratio of AI conversion into AII were significantly increased in LRS rats (P < 0.05), but decreased in HH and SHH rats (more markedly in HH rats). AVP increased significantly in LRS rats, and also showed an increasing trend in HH and SHH, but no significance was found (P > 0.05). The action of humoral factors in PH formation was discussed.
观察了通过心外左向右分流（LRS）、低压缺氧（HH）以及分流加HH（SHH）诱导的肺动脉高压（PH）Wistar大鼠的血浆肾素活性（RA）、血管紧张素（AI）转化为血管紧张素II（AII）的浓度和比率以及精氨酸加压素（AVP）水平。与正常对照大鼠相比，LRS和SHH大鼠的RA呈上升趋势，尽管无统计学意义（P>0.05）。HH大鼠未发生变化。LRS大鼠中AI转化为AII的浓度和比率显著升高（P<0.05），但在HH和SHH大鼠中降低（HH大鼠更明显）。LRS大鼠中AVP显著升高，在HH和SHH中也呈上升趋势，但无统计学意义（P>0.05）。讨论了体液因子在PH形成中的作用。
