Tauchi K, Kanehara H
Physiology and Biochemistry Section, Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
Exp Nephrol. 1996 Jan-Feb;4(1):60-4.
We examined the involvement of the renin-angiotensin system in the maintenance of hypertension of the rat with congenital hydronephrosis having no urinary tract obstruction. The congenital hydronephrosis rat (HNR) had a significantly higher systolic blood pressure (181 +/- 9.5 mm Hg in the male bilateral hydronephrosis rat, BHN, at 13 weeks of age, n = 10) than control Wistar-Imamichi rats (126 +/- 5.8 mm Hg). The plasma renin activity and plasma angiotensin-II concentration of BHN were decreased to 20.1 and 24.6% of those of control rats, respectively. There was a negative correlation between plasma angiotensin-II concentration and blood pressure. In addition, the effect of captopril and indomethacin on the high blood pressure of BHNs was similar to that of human low-renin essential hypertension. These findings suggest that the renin-angiotensin system activity was markedly lowered and that the involvement of the system in the maintenance of hypertension in HNRs is small.
我们研究了肾素 - 血管紧张素系统在无尿路梗阻的先天性肾积水大鼠高血压维持中的作用。先天性肾积水大鼠（HNR）的收缩压显著高于对照的Wistar-Imamichi大鼠（13周龄雄性双侧肾积水大鼠，BHN，收缩压为181±9.5 mmHg，n = 10）（对照大鼠收缩压为126±5.8 mmHg）。BHN的血浆肾素活性和血浆血管紧张素II浓度分别降至对照大鼠的20.1%和24.6%。血浆血管紧张素II浓度与血压呈负相关。此外，卡托普利和吲哚美辛对BHN高血压的作用与人低肾素性原发性高血压相似。这些发现表明，肾素 - 血管紧张素系统活性明显降低，且该系统在HNR高血压维持中的作用较小。
