Tyagi P, Patil S A, Girdhar B K, Katoch K, Sengupta U
Central JALMA Institute for Leprosy, Taj Ganj, Agra, India.
Int J Lepr Other Mycobact Dis. 1992 Dec;60(4):562-9.
The effect of circulating immune complexes, isolated in the form of polyethylene glycol (PEG) precipitates from leprosy patients, on lymphocyte proliferation was studied. The results obtained showed that PEG precipitates obtained from the borderline lepromatous/lepromatous (BL/LL) types of leprosy patients and those undergoing erythema nodosum leprosum (ENL) had significant suppressive effects on the lymphocyte proliferation induced by Mycobacterium leprae antigens in healthy responders. The percent decreases in the mean values of delta cpm in the presence of PEG precipitates from the BL/LL and ENL groups were found to be 46.8 +/- 22.4 and 65.0 +/- 24.3, respectively. However, no significant suppressive effects (except for ENL PEG precipitates) of these PEG precipitates were observed on the lymphocyte proliferation induced by tuberculin (PPD). Further, PEG precipitates alone (in the absence of M. leprae antigen) from the BL/LL and ENL groups were found to have no effect on the lymphocyte proliferation.
研究了从麻风病患者体内以聚乙二醇（PEG）沉淀形式分离出的循环免疫复合物对淋巴细胞增殖的影响。所得结果表明，从界线类偏瘤型/瘤型（BL/LL）麻风病患者以及那些正在经历麻风结节性红斑（ENL）的患者体内获得的PEG沉淀物，对健康应答者中麻风杆菌抗原诱导的淋巴细胞增殖具有显著的抑制作用。发现BL/LL组和ENL组的PEG沉淀物存在时，δcpm平均值的降低百分比分别为46.8±22.4和65.0±24.3。然而，未观察到这些PEG沉淀物（ENL PEG沉淀物除外）对结核菌素（PPD）诱导的淋巴细胞增殖有显著抑制作用。此外，发现BL/LL组和ENL组单独的PEG沉淀物（在无麻风杆菌抗原的情况下）对淋巴细胞增殖没有影响。
