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[通过刺激丘脑腹中间核治疗帕金森震颤及其他异常运动的新可能性]

[Novel possibilities for treatment of parkinsonian tremor and other abnormal movements by stimulation of the nucleus ventralis intermedius thalami].

作者信息

Laine E, Blond S, Caparros-Lefebvre D

机构信息

Clinique neurochirurgicale du C.H.U. de Lille.

出版信息

Bull Acad Natl Med. 1992 Nov;176(8):1147-56; discussion 1156-7.

PMID:1300221
Abstract

Chronic thalamic stereotactic stimulation has been performed in 22 patients with disabling tremor and poor response to drug therapy: 17 parkinsonian tremors and 5 essential tremors. Our first results are presented with a mean follow-up of 26 months. Parkinsonian tremors 17 = complete disappearance: 12, clear improvement: 5. Essential tremors 5 = complete disappearance: 3, clear improvement: 1, failure 1 cured by thalamotomy. Choreic or ballistic dyskinesias 7 = complete disappearance: 5, clear improvements: 2. Dystonic dyskinesias 3 = complete disappearance: 2, failure: 1. This new stereotactic procedure permits to control easily not only tremor but also L-Dopa induced dyskinesias: choreic or ballistic dyskinesias and biphasic dystonic dyskinesias. The place of this surgical treatment among the other therapeutic possibilities is discussed.

摘要

对22例震颤严重且药物治疗效果不佳的患者进行了慢性丘脑立体定向刺激:其中17例为帕金森震颤,5例为特发性震颤。本文给出了平均随访26个月的初步结果。帕金森震颤17例:完全消失12例,明显改善5例。特发性震颤5例:完全消失3例,明显改善1例,1例无效后经丘脑切开术治愈。舞蹈样或投掷样运动障碍7例:完全消失5例,明显改善2例。张力障碍性运动障碍3例:完全消失2例,无效1例。这种新的立体定向手术不仅能轻松控制震颤,还能控制左旋多巴诱发的运动障碍:舞蹈样或投掷样运动障碍以及双相张力障碍性运动障碍。本文还讨论了这种手术治疗在其他治疗方法中的地位。

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