Skiba K, Misterka S, Kateusz J
Katedra i Klinika Chirurgii Urazowej AM, Wrocławiu.
Polim Med. 1992;22(3):71-5.
Treatments included 20 patients for whom in the marrow cavity 1 chain of Septopal was inserted, and 10 patients for whom 2-4 chains were inserted. Before the planned operation the mark of the level of urea and of creatinine in the blood serum was made for the patients, and the clearance of creatinine was calculated. It was stated that usage of Gentamycin-Septopal for people who do not let know about the suffering from a kidney disease in the past, and the laboratory tests before the operation do not show deviations from the standard is a safe treatment recommended in prophylaxis and in treatment of blood-derived and traumatic inflammations of bones. Because of nephrotoxicity of Gentamycin the function of kidneys should be monitored before and during treatment with that medicine. Gentamycin can be connected with other antibiotics in order to improve the efficiency of its work.
对20名患者在骨髓腔内插入1条Septopal链，对10名患者插入2 - 4条链。在计划手术前，为患者测定血清尿素和肌酐水平，并计算肌酐清除率。结果表明，对于既往未患肾病且术前实验室检查未显示偏离标准的人群，使用庆大霉素 - Septopal是预防和治疗血源性及创伤性骨炎症的一种安全推荐治疗方法。由于庆大霉素具有肾毒性，在使用该药物治疗前和治疗期间应监测肾功能。庆大霉素可与其他抗生素联合使用，以提高其疗效。
