[Studies of the effect of gentamicin on the kidneys of healthy young rats. I. Effect of gentamicin on serum urea and creatinine levels and urinary protein levels in experimental animals].

Gentamicin was given to rats in the doses and intervals equivalent to those used in the patients. It has been established that the dose of 3 mg/kg/day did not affect the urea and creatinine plasma levels. The doses of 6 and 12 mg/kg/day for 10 consecutive days caused an increase of urea and creatinine plasma levels, proteinuria, erythrocyturia and cylindruria which were statistically significant. These changes were directly dose related and subsided after drug withdrawal.