Bajgar J, Skopec F
Purkynĕ Military Medical Academy, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1992;35(4):337-46.
Simple method of continual monitoring of the rat blood cholinesterase activity in vivo was used to demonstrate its inhibition following i. m. administration of acridine and carbamate inhibitors. Another type of inhibition was demonstrated for different routes of administration of highly toxic organophosphate, VX. Reactivation of the blood cholinesterase was also monitored following intoxication with VX and soman and treated with obidoxime and atropine. This continual determination of cholinesterase activity represents an useful approach to study effects of cholinesterase inhibitors.
采用简单的体内连续监测大鼠血液胆碱酯酶活性的方法，以证明肌肉注射吖啶和氨基甲酸酯抑制剂后该酶活性受到抑制。对于剧毒有机磷化合物VX的不同给药途径，证明了另一种抑制类型。在用VX和梭曼中毒并用双复磷和阿托品治疗后，也监测了血液胆碱酯酶的重新激活情况。这种连续测定胆碱酯酶活性是研究胆碱酯酶抑制剂作用的一种有用方法。
