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[多原发性肿瘤患者及家族性乳腺癌患者的染色体脆性位点]

[Chromosome fragile sites in patients with multiple primary tumors and familial forms of breast cancer].

作者信息

Kuleshov N P, Cortina-Guerrero G D, Razinkova G A, Gar'kavtseva R F, Nefedov M D, Kuzina N Iu, Letiagin V P

出版信息

Vopr Onkol. 1992;38(2):160-6.

PMID:1300700
Abstract

An analysis was carried out of chromosomal site-fragility in patients with primary multiple tumors and familial breast cancer. A possible correlation is discussed between fragile sites, breakpoints in chromosome rearrangements in cancer patients and the localization of oncogenes mapped in chromosomal regions involved in said rearrangements.

摘要

对原发性多发性肿瘤和家族性乳腺癌患者的染色体位点脆性进行了分析。讨论了脆性位点、癌症患者染色体重排中的断点与定位在所述重排涉及的染色体区域中的癌基因之间可能存在的相关性。

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