Sokova O I, Kirichenko O P, Kulagina O E, Konstantinova L N, Chebotarev A N, Fleĭshman E V
Genetika. 1997 Sep;33(9):1297-302.
Karyotypic structural aberrations in tumor cells and chromosome constitutive fragile sites (cFSs) in peripheral blood lymphocytes were studied in ten patients with colorectal adenocarcinoma Most chromosome breakpoints (38 out of 40, i.e., 95.0%) were shown to be located within cFSs in tumor cells. Expression of 24 out of 137 cFSs in patients was higher than that in healthy donors. Four of these cFSs (6q26, 7q36, 16q23, and 17q21), were involved in the formation of nonrandom tumor cell chromosome markers most characteristic of colorectal neoplasms. The frequency of damages induced within these sites was analyzed in each patient. Expression of 7q36, 16q23, and 17q21 was increased in blood cells of patients carrying specific chromosome rearrangements with the breakpoints within these sites. The association between nonrandom chromosome aberrations in tumor cells and cFSs in normal cells is discussed.
对10例结肠腺癌患者的肿瘤细胞中的核型结构畸变以及外周血淋巴细胞中的染色体组成型脆性位点（cFSs）进行了研究。结果显示，大多数染色体断点（40个中的38个，即95.0%）位于肿瘤细胞的cFSs内。患者137个cFSs中有24个的表达高于健康供体。其中4个cFSs（6q26、7q36、16q23和17q21）参与了结肠肿瘤最具特征性的非随机肿瘤细胞染色体标志物的形成。分析了每位患者这些位点内诱导损伤的频率。在携带这些位点内有断点的特定染色体重排的患者血细胞中，7q36、16q23和17q21的表达增加。讨论了肿瘤细胞中的非随机染色体畸变与正常细胞中的cFSs之间的关联。
