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[恶性皮肤黑色素瘤和胃癌患者的T免疫系统对主动非特异性免疫疗法的反应]

[The reaction of the T-immunity system in patients with malignant skin melanoma and stomach cancer to active nonspecific immunotherapy].

作者信息

Glinkina L S, Bruvere R Zh

出版信息

Vopr Onkol. 1992;38(6):659-66.

PMID:1300766
Abstract

Changes in E-receptor-bearing T-lymphocyte level (total and that of active T-lymphocytes) were studied in peripheral blood and resected material obtained from skin malignant melanoma and gastric cancer patients treated with rigvir, an original immunomodulator of the viral origin. Injection of rigvir into peripheral blood was followed by an increase in active T-lymphocyte level and stimulated their migration into tumor. The latter was determined by stage and rate of tumor advancement.

摘要

对皮肤恶性黑色素瘤和胃癌患者外周血及切除组织中携带E受体的T淋巴细胞水平(总数及活性T淋巴细胞水平)的变化进行了研究,这些患者接受了病毒源原始免疫调节剂里格非尔(Rigvir)的治疗。将里格非尔注入外周血后,活性T淋巴细胞水平升高,并刺激它们迁移至肿瘤部位。后者由肿瘤进展的阶段和速度决定。

相似文献

1
[The reaction of the T-immunity system in patients with malignant skin melanoma and stomach cancer to active nonspecific immunotherapy].[恶性皮肤黑色素瘤和胃癌患者的T免疫系统对主动非特异性免疫疗法的反应]
Vopr Onkol. 1992;38(6):659-66.
2
[The cellular immunity indices of patients with malignant melanoma using the viral immunomodulator rigvir].[使用病毒免疫调节剂里格非尔治疗恶性黑色素瘤患者的细胞免疫指标]
Vopr Onkol. 1992;38(5):540-7.
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[The humoral immunity indices of patients with malignant skin melanoma using the viral immunomodulator rigvir].[使用病毒免疫调节剂Rigvir的恶性皮肤黑色素瘤患者的体液免疫指标]
Vopr Onkol. 1992;38(5):534-40.
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Active immunotherapy with ultraviolet B-irradiated autologous whole melanoma cells plus DETOX in patients with metastatic melanoma.对转移性黑色素瘤患者采用紫外线B照射的自体全黑色素瘤细胞加DETOX进行主动免疫治疗。
Clin Cancer Res. 1998 Mar;4(3):619-27.
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[Changes in certain immunological parameters in patients with malignant skin melanoma].
Orv Hetil. 1985 Apr 7;126(14):819-26.
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[Nonspecific cell-mediated immunity in gastric cancer patients - with special reference to immuno-reactivity of the regional lymph node and preoperative immunotherapy].胃癌患者的非特异性细胞介导免疫——特别提及区域淋巴结的免疫反应性及术前免疫治疗
Nihon Geka Gakkai Zasshi. 1983 Aug;84(8):679-91.
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[Vaccination therapy of melanoma].[黑色素瘤的疫苗接种疗法]
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[Evaluation of T- and B-cell immunity of regional lymph nodes in patients with skin melanoma and prognosis of the disease].[皮肤黑色素瘤患者区域淋巴结的T细胞和B细胞免疫评估及疾病预后]
Vopr Onkol. 1983;29(12):18-20.
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Immunologic function in humans before and after hyperthermia and chemotherapy for disseminated malignancy.
J Natl Cancer Inst. 1977 Apr;58(4):905-11. doi: 10.1093/jnci/58.4.905.
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Viral oncolysate in the management of malignant melanoma. I. Preparation of the oncolysate and measurement of immunologic responses.
Cancer. 1977 Aug;40(2):672-9. doi: 10.1002/1097-0142(197708)40:2<672::aid-cncr2820400213>3.0.co;2-y.

引用本文的文献

1
Effect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin .溶瘤性ECHO-7病毒Rigvir®对人源细胞系活力的影响
J Cancer. 2018 Feb 28;9(6):1033-1049. doi: 10.7150/jca.23242. eCollection 2018.
2
Oncolytic virotherapy including Rigvir and standard therapies in malignant melanoma.溶瘤病毒疗法,包括 Rigvir 和恶性黑色素瘤的标准疗法。
Oncolytic Virother. 2017 Feb 9;6:11-18. doi: 10.2147/OV.S100072. eCollection 2017.
3
Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in melanoma patients after surgical excision of the tumour in a retrospective study.
一项回顾性研究表明,经改良的ECHO-7病毒Rigvir免疫疗法(溶瘤病毒疗法)可延长黑色素瘤患者肿瘤手术切除后的生存期。
Melanoma Res. 2015 Oct;25(5):421-6. doi: 10.1097/CMR.0000000000000180.