Glinkina L S, Heisele O G, Garklava R R, Muceniece A J
Vopr Onkol. 1992;38(5):534-40.
The effect of a viral immunomodulator rigvir on humoral immunity was studied in patients with skin malignant melanoma. Peripheral blood levels of B-lymphocytes, IgA, G and M and circulating immune complexes were assayed and immunoglobulin/B-cell ratio (Ig/B) calculated. Preoperative treatment with rigvir brought the indexes of humoral immunity to normal. Response of melanoma patients to rigvir treatment was different from that seen in healthy subjects and was determined by the course of disease.
在皮肤恶性黑色素瘤患者中研究了病毒免疫调节剂里格非尔（Rigvir）对体液免疫的影响。检测了外周血B淋巴细胞、IgA、G和M水平以及循环免疫复合物，并计算了免疫球蛋白/B细胞比值（Ig/B）。术前用里格非尔治疗可使体液免疫指标恢复正常。黑色素瘤患者对里格非尔治疗的反应与健康受试者不同，且取决于疾病进程。
