Reztsova V V, Filov V A, Stukov A N
Vopr Onkol. 1992;38(6):718-23.
The study was concerned with a relationship between a decrease in NAD concentration and inhibition of precursor utilization for NAD biosynthesis, on the one hand, and inhibition of Ehrlich ascitic carcinoma growth in response to treatment with embichin, cyclophosphamide, thiophosphamide, adriablastin and methotrexate, on the other. The antitumor effect of drugs was found to be determined by degree of inhibition of precursor utilization for NAD biosynthesis but not by a decrease in NAD level. A relationship between alteration of synchronous induction of NAD and poly (ADP-ribose) biosynthesis rates and reversibility of the antitumor effect of drugs is discussed.
该研究一方面关注NAD浓度降低与NAD生物合成前体利用受抑制之间的关系，另一方面关注埃利希腹水癌在接受恩比兴、环磷酰胺、硫磷酰胺、阿霉素和甲氨蝶呤治疗后生长受抑制的情况。研究发现，药物的抗肿瘤作用取决于NAD生物合成前体利用的抑制程度，而非NAD水平的降低。文中还讨论了NAD与聚（ADP - 核糖）生物合成速率同步诱导变化与药物抗肿瘤作用可逆性之间的关系。
