Sakai K, Sakurai Y, Sakuta M, Iwata M
Department of Neurology, Japanese Red Cross Medical Center.
Rinsho Shinkeigaku. 1992 Nov;32(11):1227-31.
A 71-year-old right-handed man presented writing and reading difficulties as well as naming difficulties. Neuropsychological examinations revealed mild fluent type aphasia accompanied by alexia and agraphia predominantly affecting kanji and also severe naming difficulties. Brain MRI showed cerebral subcortical hemorrhage extending from the anterior one-third of the left temporal lobe to the temporo-occipital junction involving the fusiform gyrus. The analysis of the several reported cases with severe alexia with agraphia for kanji including ours revealed a close correlation between the severity of kanji writing disturbances and that of naming difficulties. It was also shown that cases with severe naming difficulties had lesion extending anteriorly to the anterior middle temporal gyrus or medially to the parahippocampal gyrus, suggesting that the disconnection between the parahippocampal gyrus and other cortices including the temporal lobe was essential for production of naming difficulties.
一名71岁的右利手男性出现书写、阅读困难以及命名困难。神经心理学检查显示为轻度流利型失语,伴有失读症和失写症,主要影响汉字,且存在严重的命名困难。脑部磁共振成像显示脑皮质下出血,从左侧颞叶前三分之一延伸至颞枕交界,累及梭状回。对包括我们的病例在内的几例报告的严重汉字失读失写症病例分析显示,汉字书写障碍的严重程度与命名困难的严重程度密切相关。研究还表明,存在严重命名困难的病例,其病变向前延伸至颞中前回或向内延伸至海马旁回,这表明海马旁回与包括颞叶在内的其他皮质之间的联系中断是产生命名困难的关键。