6至24个月儿童中氯喹的药代动力学
Pharmacokinetics of mefloquine in children aged 6 to 24 months.
作者信息
Singhasivanon V, Chongsuphajaisiddhi T, Sabcharoen A, Attanath P, Webster H K, Wernsdorfer W H, Sheth U K, Djaja Lika I
机构信息
Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
出版信息
Eur J Drug Metab Pharmacokinet. 1992 Oct-Dec;17(4):275-9. doi: 10.1007/BF03190160.
The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 250 mg+sulfadoxine 500 mg+pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight. All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients.
该研究在12名年龄在6个月至2岁之间、患有无并发症恶性疟原虫疟疾的儿童中进行，这些儿童被收治于曼谷热带病医院。他们接受了以MSP（甲氟喹250毫克+周效磺胺500毫克+乙胺嘧啶25毫克）形式的甲氟喹治疗，甲氟喹碱基的单剂量为25毫克/千克体重。所有患儿均治愈（随访28天），且副作用极小。对9例患儿进行了药代动力学参数测定。结果显示，本研究中（6至24个月大的儿童）的平均驻留时间（MRT）、半衰期（t1/2）和达峰时间（tmax）与5至12岁儿童的值相当，但短于成年患者。6至24个月大儿童的血药峰浓度（Cmax）和药时曲线下面积（AUC）与5至12岁儿童相当，但远高于成年患者。本研究中的表观分布容积（Vz/f）值与5至12岁儿童相当，但低于成年患者。
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