Williamson J R, Arrigoni-Martelli E
Department of Pathology, Washington University School of Medicine, St. Louis.
Int J Clin Pharmacol Res. 1992;12(5-6):247-52.
Investigations were initiated to examine the rate of imbalances in carnitine metabolism in the pathogenesis of diabetic vascular changes in the retina, peripheral nerves, aorta and kidney. It appears that glucose/diabetes-induced vascular dysfunction and early vascular structural changes are mediated by hyperglycaemic hypoxia i.e. glucose-induced metabolic imbalances that cause an increase in the reduced nicotinamide-adenine dinucleotide/nicotinic acid dehydrogenase ratio, and are linked to imbalances in carnitine metabolism.
已开展调查以研究在视网膜、外周神经、主动脉和肾脏的糖尿病血管病变发病机制中肉碱代谢失衡的发生率。似乎葡萄糖/糖尿病诱导的血管功能障碍和早期血管结构变化是由高血糖缺氧介导的，即葡萄糖诱导的代谢失衡导致还原型烟酰胺腺嘌呤二核苷酸/烟酰胺酸脱氢酶比率增加，并与肉碱代谢失衡有关。
