Berger R, Jensen A, Krieglstein J, Steigelmann J P
Zentrum für Frauenheilkunde und Geburtshilfe der Justus-Liebig-Universität, Giessen, Germany.
J Dev Physiol. 1992 Sep;18(3):125-8.
In immature fetuses circulatory centralization caused by acute asphyxia is less effective than that in mature fetuses (Jensen & Berger, 1991). This suggests that cerebral oxygenation may be poor in immature fetuses during asphyxia. On the other hand cerebral oxygen consumption is lower in immature than that in mature fetuses. To determine, whether or not there is an imbalance between oxygen supply and demand in one or the other group, we compared the time course of the changes of cerebral concentrations of both high-energy phosphates and glycolytic intermediates between immature and mature guinea pig fetuses during acute asphyxia caused by arrest of uterine blood flow. The fall in the cerebral concentrations of adenosine triphosphate and glucose, and the rise in those of adenosine monophosphate and lactate were slower in immature than in mature fetuses. There were no differences between the levels of cerebral adenosine diphosphate and creatine phosphate of the two groups. From these results we conclude that during acute asphyxia the imbalance between cerebral oxygen supply and demand is less marked in immature than in mature fetuses.
在未成熟胎儿中，急性窒息引起的循环集中化比成熟胎儿中的效果要差（詹森和伯杰，1991年）。这表明未成熟胎儿在窒息期间脑氧合作用可能较差。另一方面，未成熟胎儿的脑氧消耗量比成熟胎儿低。为了确定这两组中是否存在供需失衡，我们比较了未成熟和成熟豚鼠胎儿在子宫血流阻断引起的急性窒息期间高能磷酸盐和糖酵解中间产物脑浓度变化的时间过程。未成熟胎儿中三磷酸腺苷和葡萄糖的脑浓度下降以及一磷酸腺苷和乳酸的脑浓度上升比成熟胎儿中要慢。两组的脑二磷酸腺苷和磷酸肌酸水平没有差异。从这些结果我们得出结论，在急性窒息期间，未成熟胎儿脑氧供需失衡比成熟胎儿中不那么明显。
