Berger R, Jensen A, Krieglstein J, Steigelmann J P
Zentrum für Frauenheilkunde und Geburtshilfe, Justus-Liebig-Universität, Germany.
J Dev Physiol. 1991 Dec;16(6):317-9.
During development fetal arterial oxygen tension falls, whereas cerebral oxygen consumption rises due to an increase in cerebral metabolism. To compensate for this increase in oxygen consumption, blood flow and therefore oxygen delivery to the cerebrum rises. To determine whether during development oxygen delivery to the cerebrum meets cerebral oxygen consumption, we measured the concentrations of high-energy phosphates and glycolytic intermediates in the cerebral cortex of fetal guinea pigs at different gestational ages. During development there was no change in the concentrations of adenosine triphosphate, creatine phosphate, adenosine monophosphate, and lactate. However, cerebral concentrations of adenosine diphosphate increased and those of glucose decreased. Our results suggest that the increase in fetal cerebral oxygen delivery during development meets cerebral oxygen consumption with increasing gestational age. We speculate that the measured rise in the concentrations of adenosine diphosphate may accelerate glycolysis during development and therefore may cause a rise in both cerebral blood flow to maintain oxygen delivery.
在发育过程中，胎儿动脉血氧张力下降，而由于脑代谢增加，脑氧消耗上升。为了补偿这种氧消耗的增加，血流量以及因此输送到大脑的氧量增加。为了确定在发育过程中输送到大脑的氧量是否满足脑氧消耗，我们测量了不同胎龄的豚鼠胎儿大脑皮层中高能磷酸盐和糖酵解中间产物的浓度。在发育过程中，三磷酸腺苷、磷酸肌酸、一磷酸腺苷和乳酸的浓度没有变化。然而，二磷酸腺苷的脑浓度增加，而葡萄糖的浓度下降。我们的结果表明，发育过程中胎儿脑氧输送的增加随着胎龄的增加满足了脑氧消耗。我们推测，所测得的二磷酸腺苷浓度的升高可能在发育过程中加速糖酵解，因此可能导致脑血流量增加以维持氧输送。
