Arditti J, Bourdon J H, Jean P, Landi H, Nasset D, Jouglard J, Thirion X
Centre Anti-Poisons, Hôpital Salvator, Marseille.
Therapie. 1992 Nov;47(6):561-2.
Buprenorphine, a synthetic central analgesic, marketed since 1987, was rapidly suspected to be subject to abuse. We tried to confirm this abuse in the context of our analytical activity at the Drug Dependence Evaluation and Information Centre. The study was based on 50 drug addicts admitted to Marseille Hospital between June and October 1992. Buprenorphine and its N-dealkylated metabolite were identified in the urine by high performance liquid chromatography equipped with a diode array detector. Nine (18%) of the 50 samples analysed were positive for buprenorphine and/or norbuprenorphine, with a confidence interval of 8 to 28%, which confirms the existence of abuse of this analgesic.
丁丙诺啡是一种合成中枢镇痛药，自1987年上市以来，很快就被怀疑易被滥用。我们试图在药物依赖性评估和信息中心的分析活动中证实这种滥用情况。该研究基于1992年6月至10月间收治于马赛医院的50名吸毒成瘾者。通过配备二极管阵列检测器的高效液相色谱法在尿液中鉴定出丁丙诺啡及其N-去烷基代谢物。在分析的50个样本中，有9个（18%）丁丙诺啡和/或去甲丁丙诺啡呈阳性，置信区间为8%至28%，这证实了这种镇痛药存在滥用现象。
