Suonio S, Ryynänen M, Olkkonen H, Castren O
Int J Gynaecol Obstet. 1976;14(3):268-72. doi: 10.1002/j.1879-3479.1976.tb00609.x.
Cardiopulmonary parameters (minute volume, heart rate, stroke volume, right heart, pulmonary and left heart blood volumes), blood pressure and placental blood flow were evaluated in 20 normal patients, nine patients with preeclamptic disease and 12 with essential hypertension in late pregnancy before and 60 minutes after a single i.m. dose of 10 mg of ritodrine hydrochloride. The drug caused a statistically significant increase in heart rate in all the patient groups, while the systolic and diastolic blood pressures were only slightly affected. Minute volume was unchanged in the group of normal patients, but in both hypertensive groups there was a significant increase. The placental perfusion index was statistically nearly significantly decreased in the group of uncomplicated pregnancies, statistically significantly increased in preeclamptic patients, and not affected in the group with essential hypertension. Ritodrine hydrochloride medication can be expected to have a positive effect on placental blood flow only in preeclamptic disease, and then probably in the milder forms of the disease.
对20名正常孕妇、9名先兆子痫患者和12名妊娠晚期原发性高血压患者，在单次肌肉注射10毫克盐酸利托君前及注射后60分钟，评估其心肺参数（每分通气量、心率、每搏输出量、右心、肺和左心血容量）、血压及胎盘血流量。该药物使所有患者组的心率出现统计学上的显著增加，而收缩压和舒张压仅受到轻微影响。正常孕妇组的每分通气量未变，但在两个高血压组中均显著增加。单纯妊娠组的胎盘灌注指数在统计学上几乎显著降低，先兆子痫患者组则在统计学上显著增加，原发性高血压组未受影响。仅在先兆子痫疾病中，且可能仅在病情较轻的形式下，预计盐酸利托君药物对胎盘血流量有积极作用。
