Mårtensson L, Sjöquist P O, Bjellin L, Carter A M
Am J Obstet Gynecol. 1979 Oct 1;135(3):318-21. doi: 10.1016/0002-9378(79)90697-5.
The effect of ritodrine hydrochloride on uterine blood flow was investigated in near-term guinea pigs. The infusion of ritodrine in doses sufficient to inhibit uterine activity provoked tachycardia, and the cardiac output tended to rise. The percentage of cardiac output reaching the gravid uterus did not alter during the infusion of 12 micrograms per minute of ritodrine but decreased from 12% to 10% when the infusion rate was 120 micrograms per minute. There was an increase in the myoendothelial fraction of cardiac output in both instances, whereas the placental fraction decreased at the higher rate of infusion. Perfusion of the myoendothelial tissue improved during the infusion of 12 or 120 micrograms per minute of ritodrine, increasing by 25% and 18% respectively. No significant alteration occurred in the perfusion of the placental tissue.
在近足月豚鼠中研究了盐酸利托君对子宫血流的影响。输注足以抑制子宫活动剂量的利托君会引发心动过速，心输出量有上升趋势。在每分钟输注12微克利托君期间，到达妊娠子宫的心输出量百分比没有改变，但当输注速率为每分钟120微克时，该百分比从12%降至10%。在这两种情况下，心输出量的肌内皮部分均增加，而在较高输注速率下胎盘部分减少。在每分钟输注12或120微克利托君期间，肌内皮组织的灌注得到改善，分别增加了25%和18%。胎盘组织的灌注没有发生显著改变。
