Wang S Y
Beijing Hospital.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1992;27(5):265-7, 318.
Nineteen guinea pigs of one month and 11 of 30 months were given high fat diet for 3 months to produce hyperlipidemia; 16 of them followed by 3 months' normal diet to resume blood lipid level; 27 for control. The results showed that: The serum cholesterol level of the experimental groups was markedly elevated (P < 0.01) with fatty degeneration of liver. Damages in OHC, IHC, cells of stria vascularis and few myelin sheaths of cochlear nerve were seen in all experimental animals, and the reduction of cochlear damages was not seen in those animals with blood lipid level resumed to normal. Auditory dysfunction was very marked as shown by ABR in the old animals with hyperlipidemia as compared with controls (P < 0.01).
将19只1月龄和11只30月龄的豚鼠给予高脂饮食3个月以产生高脂血症；其中16只随后给予3个月正常饮食以恢复血脂水平；27只为对照组。结果显示：实验组血清胆固醇水平显著升高（P<0.01），伴有肝脏脂肪变性。在所有实验动物中均可见外毛细胞、内毛细胞、血管纹细胞及少数耳蜗神经髓鞘受损，且血脂恢复正常的动物耳蜗损伤未见减轻。与对照组相比，高脂血症老龄动物的听性脑干反应显示听觉功能障碍非常明显（P<0.01）。
