Kohn S, Fradis M, Pratt H, Zidan J, Podoshin L, Robinson E, Nir I
Unit of Electron Microscopy, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Laryngoscope. 1988 Aug;98(8 Pt 1):865-71. doi: 10.1288/00005537-198808000-00015.
The toxic effects of cisplatin (cis-diamminedichloroplatinum [II]) on the organ of Corti are well established. Few and conflicting data on this drug's effects on the stria vascularis exist. The present study presents animal experiments on the toxic effects of cisplatin in the stria vascularis and in the organ of Corti. Cisplatin-induced toxicity in albino and pigmented guinea pigs was evaluated morphologically and functionally, using light and transmission electron microscopy as well as auditory brainstem-evoked potentials on the organ of Corti and the stria vascularis. The results showed variability in hearing thresholds, ranging from no change to hearing loss of 30 dB, and prominent damage in the organ of Corti and in the stria vascularis. The toxic effects to both the organ of Corti and the stria vascularis should be considered when cisplatin is used in chemotherapy.
顺铂（顺二氨二氯铂[II]）对柯蒂氏器的毒性作用已得到充分证实。关于这种药物对血管纹的影响，现有数据很少且相互矛盾。本研究展示了顺铂对血管纹和柯蒂氏器毒性作用的动物实验。利用光学显微镜、透射电子显微镜以及柯蒂氏器和血管纹的听觉脑干诱发电位，从形态学和功能上评估了顺铂对白化豚鼠和有色豚鼠的诱导毒性。结果显示，听力阈值存在差异，从无变化到听力损失30分贝不等，且柯蒂氏器和血管纹均有明显损伤。在化疗中使用顺铂时，应考虑其对柯蒂氏器和血管纹的毒性作用。
