Jiang H W, Qian Z H, Weng W L
Xiyuan Hospital, China Academy of TCM, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Nov;12(11):663-5, 644.
55 cases of Qi-deficiency and Blood-Stasis syndrome of coronary heart disease (CHD) and angina pectoris (AP) were divided randomly into two groups. Qi Xue granule (QXG) was administered to 30 cases of treated group, while compound Salvia tablet (CST) was administered to 25 cases of control group. Besides, both group were also given one placebo tablet or granule so as to eliminate the patient's psychological effects.
(1) Effects on clinical symptoms: Total effective rate for AP: 90% in QXG group, marked effective rate and effective rate for ischemic ECG changes were 30% and 46.6% respectively. All of these were better than that of CST group significantly (P < 0.05). Besides, QXG group could alleviate symptoms including asthenia. (2) Effects on submaximal paddle work load test: QXG group could prolong the capacity of exercise (from 336.2 +/- 34.7 to 437.5 +/- 43.8 seconds, P < 0.05), magnify the work load (from 73 +/- 7.18 to 94 +/- 8.5 W, P < 0.05) and elevate the ST segment (from 0.218 +/- 0.03 to 0.176 +/- 0.03 mV) significantly in comparison with CST group, which had little change only. (3) Effects on plasma TXB2, 6-keto-PGF1 alpha (6 Kp) level and ration of TXB2/6Kp in 10 normal subjects were 165 +/- 12.1 pg/ml, 142.6 +/- 17.4 pg/ml and 1.16 +/- 0.19 pg/ml respectively, while in 36 cases AP were 390.6 +/- 14.3, 106.0 +/- 7.9 and 3.67 +/- 0.85 pg/ml respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
将55例冠心病（CHD）和心绞痛（AP）气虚血瘀证患者随机分为两组。治疗组30例给予气血颗粒（QXG），对照组25例给予复方丹参片（CST）。此外，两组均给予1片安慰剂片剂或颗粒剂以消除患者的心理作用。
（1）对临床症状的影响：AP的总有效率：QXG组为90%，缺血性心电图改变的显效率和有效率分别为30%和46.6%。所有这些均显著优于CST组（P<0.05）。此外，QXG组可缓解包括乏力在内的症状。（2）对次极量平板运动负荷试验的影响：与CST组相比，QXG组可显著延长运动能力（从336.2±34.7秒延长至437.5±43.8秒，P<0.05），增加工作负荷（从73±7.18瓦增加至94±8.5瓦，P<0.05）并抬高ST段（从0.218±0.03毫伏降至0.176±0.03毫伏），而CST组仅有微小变化。（3）对血浆TXB2、6-酮-前列腺素F1α（6-Kp）水平及TXB2/6-Kp比值的影响：10例正常受试者的血浆TXB2、6-Kp水平及TXB2/6-Kp比值分别为165±12.1皮克/毫升、142.6±17.4皮克/毫升和1.16±0.
