[Relation of changes in plasma TXB2 PGF1alpha and differentiation of signs and symptoms in traditional Chinese medicine in severe icteric hepatitis].

Clinical observations and experimental studies were made in 52 cases of chronic cholestatic hepatitis, 30 cases of chronic severe hepatitis, 30 healthy control persons, and 30 animals with experimental intrahepatic cholestasis. The results were as follows: Plasma TXB2 and PGF1 alpha were higher than their normal values both in cases of chronic cholestatic hepatitis and in cases of chronic severe hepatitis (P less than 0.01), the ratio of TXB2 and PGF1 alpha was normal in cases of chronic severe hepatitis and lower than normal value in cases of chronic cholestatic hepatitis (P less than 0.01). The cases were divided into 4 types (hepatitis due to blood stasis and blood heat, blood stasis and blood heat accompanying symptoms of fluid retention in the epigastrium, damp-heat, and composite factors) according to differentiation of symptoms and signs on the basic theories of TCM. Significant difference was found in TXB2, PGF1 alpha, PGF1 alpha/TXB2 and bilirubin when compared with each other in the 4 types of hepatitis patients (P less than 0.01). Bilirubin, TXB2, PGF1 alpha and PGF1 alpha/TXB2 in the survivors became normal or close to normal after they were treated with blood-cooling and circulation-promoting Chinese herbal medicine and prescriptions by changing their dosages according to differentiation of symptoms and signs on the basic theories of TCM. The therapeutic effect of prescription II was more satisfactory than that of prescription I. Changes of plasma TXB2 and PGF1 alpha in the experimental animals were more significant than those both in the control group and in the group treated with prescriptions I and II (P less than 0.01), but in the liver only the ratio of TXB2 and PGF1 alpha was lower than that in normal animals (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)