Tébar M, Sánchez A, Sánchez-Criado J E
Departamento de Fisiología, Facultad de Medicina, Universidad de Córdoba, Spain.
Rev Esp Fisiol. 1992 Dec;48(4):259-64.
Administration of antiprogesterone RU486 (4 mg/day) from estrus through proestrus to cyclic rats blocked ovulation. Moreover, RU486 increased basal serum concentrations of LH, PRL, testosterone and estradiol, while it decreased basal serum concentration of FSH. Both unilateral ovariectomy and antiandrogen flutamide treatment, as well as an ovulatory injection of HCG in the proestrus afternoon partially reversed, the ovulatory blockade of RU486. These results indicate that both the decreased FSH concentration and the increased testosterone concentration, as well as the reduced ovulatory LH release are responsible for the anovulatory effects of RU486.
从发情期到动情前期，向周期性发情的大鼠每日注射4毫克抗孕激素RU486会阻断排卵。此外，RU486会提高血清中促黄体生成素（LH）、催乳素（PRL）、睾酮和雌二醇的基础浓度，同时降低血清中促卵泡生成素（FSH）的基础浓度。单侧卵巢切除、抗雄激素氟他胺治疗，以及在动情前期下午进行排卵性人绒毛膜促性腺激素（HCG）注射，均可部分逆转RU486的排卵阻断作用。这些结果表明，FSH浓度降低、睾酮浓度升高以及排卵性LH释放减少，共同导致了RU486的无排卵效应。
