Wendenburg H H, Baldauf G, Barwich D
Rofo. 1976 Jan;124(1):7-11. doi: 10.1055/s-0029-1230271.
Several substances with anticonvulsent activity can lead to hypovitamenosis D after prolonged use through their effect on vitamen D metabolism in the liver. This results in abnormal bone mineralisation and produces rickets or osteomalacia. Radiological examination of the skeleton should be performed on patients receiving prolonged anticonvulsent therapy, in order to arrive at an early diagnosis. This requires an accurate knowledge of the types of bone abnormality and of their most frequent localisation. Pathological findings such as Looser's zones, epiphyseolysis or delayed development must be considered in this context. Radiological examination provides an accurate diagnosis if combined with clinical findings and important biochemical results: reduced calcium and raised alkaline phosphatase. Treatment with vitamen D must then be instituted. Healing may be complete or leave residual changes, depending on the severity of the bone changes.
几种具有抗惊厥活性的物质在长期使用后，可通过对肝脏中维生素D代谢的影响导致维生素D缺乏症。这会导致骨矿化异常，并产生佝偻病或骨软化症。对于接受长期抗惊厥治疗的患者，应进行骨骼的放射学检查，以便早期诊断。这需要准确了解骨异常的类型及其最常见的定位。在此背景下，必须考虑诸如Looser带、骨骺溶解或发育延迟等病理表现。如果结合临床发现和重要的生化结果（钙降低和碱性磷酸酶升高），放射学检查可提供准确的诊断。然后必须开始用维生素D进行治疗。根据骨改变的严重程度，愈合可能是完全的，也可能会留下残留改变。
