Kazimov M A
Gig Tr Prof Zabol. 1992(11-12):23-7.
Mixtures of cobalt and silver in ratio (0.2:0.4), (0.2:0.2) and (0.2:0.1) mg/kg were once administrated intraperitoneally and intratracheally to white rats. Metabolism of the metals was studied. Combined exposure to metals appeared to influence greatly on their toxicokinetics. The co-action between metals appears during their absorption into the blood--the elevated peritoneal absorption of cobalt depresses that of silver. The reverse relationship is demonstrated during the intratracheal insertion. Such peculiarities of co-action exist during the further stages of metabolism.
将比例为（0.2:0.4）、（0.2:0.2）和（0.2:0.1）mg/kg的钴和银混合物一次性经腹腔和气管内给予白鼠。研究了这些金属的代谢情况。金属的联合暴露似乎对其毒代动力学有很大影响。金属之间的协同作用在它们吸收进入血液的过程中出现——钴的腹腔吸收增加会抑制银的腹腔吸收。在气管内注入时则表现出相反的关系。在代谢的后续阶段也存在这种协同作用的特殊性。
