Sani A, Said H, Lokman S
Department of Otorhinolaryngology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Med J Malaysia. 1992 Dec;47(4):297-302.
A retrospective study of cases with carcinoma of the larynx seen in the Universiti Kebangsaan Malaysia (UKM) and General Hospital Kuala Lumpur (GHKL) between 1981 to 1988 was performed. The aim was to document the distribution and the pattern of behaviour of this tumour amongst our patients. There were 137 cases, the majority of whom were Chinese (54%). The peak incidence was in the seventh decade and the male to female ratio was 7.6:1. The most common symptom at presentation was hoarseness (90%). The most common histological type was squamous cell carcinoma (87%) whilst by site, transglottic involvement was commonest (55%). The overall 3 year survival rate was 68%. Supraglottic carcinoma behaved differently in that a significantly large number presented with dysphagia (33.3%) and neck nodes (42%). Compared to tumours of other sites of the larynx, they had the poorest 3 year survival rate of 50%. Amongst the T2 and T3 tumours, the results of surgery appeared better than primary radiotherapy. Considering that 26% of patients presented with stridor, 20% with neck nodes and 55% with multiple site involvement, it can be concluded that our patients present themselves late.
对1981年至1988年间在马来西亚国民大学（UKM）和吉隆坡总医院（GHKL）诊治的喉癌病例进行了一项回顾性研究。目的是记录该肿瘤在我们患者中的分布情况和行为模式。共有137例病例，其中大多数为华人（54%）。发病高峰在七十岁，男女比例为7.6:1。就诊时最常见的症状是声音嘶哑（90%）。最常见的组织学类型是鳞状细胞癌（87%），而就部位而言，跨声门受累最为常见（55%）。总体三年生存率为68%。声门上癌表现不同，相当多的患者出现吞咽困难（33.3%）和颈部淋巴结肿大（42%）。与喉其他部位的肿瘤相比，它们的三年生存率最差，为50%。在T2和T3肿瘤中，手术结果似乎优于单纯放疗。鉴于26%的患者出现喘鸣，20%出现颈部淋巴结肿大，55%出现多部位受累，可以得出结论，我们的患者就诊时已处于疾病晚期。
