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[脑血管疾病期间及之后的癫痫发作危机。78例临床分析]

[Epileptic crisis during and after cerebrovascular diseases. A clinical analysis of 78 cases].

作者信息

Milandre L, Broca P, Sambuc R, Khalil R

机构信息

Service de Neurologie, CHU Timone.

出版信息

Rev Neurol (Paris). 1992;148(12):767-72.

PMID:1303571
Abstract

Seventy-eight patients with post-stroke seizures were studied retrospectively to determine the clinical, EEG and CT features of these seizures and their prognosis. There were 57 cerebral infarctions and 21 hemorrhages. Twenty-eight (36%) initial seizures occurred within one month after the stroke (0-24 hours in 19 cases) and were classified as early-onset seizures. Fifty (64%) initial seizures occurred more than 3 months after the stroke (3-12 months in 33 cases) and were classified as late-onset seizures. Compared with a population of 1938 strokes admitted during the same period, the proportion of patients with alcohol abuse, infarction in the anterior cerebral artery territory, watershed infarcts and lobar haemorrhages was significantly greater in our series. The proportion did not vary with the nature of the stroke (infarction or hemorrhage), except for early onset seizures in which the proportion of hemorrhages was significantly greater. Nor did it vary with the cause of hemispheric infarctions (cardioembolism or atherothrombosis or others). Ninety-five percent of the lesions affected the cerebral cortex or the subcortical white matter or both. Of all 78 initial seizures, 64% were partial motor (simple or secondarily generalized); 32% were primarily generalized, and 4% were partial not motor; status epilepticus was seen in 14% of the cases. An initial EEG, performed in 76 patients was normal in 7. Among the remaining 69 patients EEG showed focal or diffuse slowing down in 63% and epileptic features in 37% (including 10 cases of PLEDs). Early post-seizure EEG and repeated recordings significantly increased the specificity of EEG.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对78例中风后癫痫患者进行回顾性研究,以确定这些癫痫发作的临床、脑电图和CT特征及其预后。其中有57例脑梗死和21例脑出血。28例(36%)首次癫痫发作发生在中风后1个月内(19例在0 - 24小时内),被归类为早发性癫痫。50例(64%)首次癫痫发作发生在中风后3个月以上(33例在3 - 12个月内),被归类为晚发性癫痫。与同期收治的1938例中风患者相比,我们的系列研究中酒精滥用、大脑前动脉区域梗死、分水岭梗死和脑叶出血患者的比例显著更高。该比例不因中风的性质(梗死或出血)而变化,但早发性癫痫中出血的比例显著更高。也不因半球梗死的原因(心源性栓塞、动脉粥样硬化血栓形成或其他)而变化。95%的病变累及大脑皮层或皮层下白质或两者。在所有78例首次癫痫发作中,64%为部分运动性发作(简单或继发性全身性发作);32%为原发性全身性发作,4%为部分非运动性发作;14%的病例出现癫痫持续状态。76例患者进行了首次脑电图检查,其中7例正常。其余69例患者中,脑电图显示局灶性或弥漫性减慢的占63%,有癫痫特征的占37%(包括10例周期性局灶性癫痫样放电)。癫痫发作后早期脑电图和重复记录显著提高了脑电图的特异性。(摘要截短于250字)

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