De Salvo L, Plumacher Z, Ríos M, Romero E, Weir J, Gómez O, Salas D
Instituto Hematológico de Occidente, Banco de Sangre del Estado Zulia, Maracaibo, Venezuela.
Invest Clin. 1992;33(4):147-52.
The results of 188 patients with acute lymphoblastic leukemia, studied between 1985 and 1990, showed that 8 cases were CD10 negative, Dr, and CD19 positive. These findings indicate cell dedifferentiation and poor prognosis. The patients age ranged from 2 to 30 years, with a mean of 11 years. The male/female ratio was 5/3. Lymph node enlargement and splenomegaly were found in the 8 patients. With the exception of one patient in whom leucopenia was present, the white cell counts were always higher than 30,000/dl. The karyotype was studied in four cases, and all of them were hyperdiploid. This is the first report in Venezuela of cases with acute lymphoblastic leukemia - CD 10 negative.
1985年至1990年间对188例急性淋巴细胞白血病患者的研究结果显示，8例患者CD10阴性、DR阴性且CD19阳性。这些发现提示细胞去分化及预后不良。患者年龄在2岁至30岁之间，平均年龄11岁。男女比例为5:3。8例患者均有淋巴结肿大及脾肿大。除1例患者有白细胞减少外，其余患者白细胞计数均高于30,000/dl。对4例患者进行了核型研究，所有患者均为超二倍体。这是委内瑞拉首例急性淋巴细胞白血病 - CD10阴性病例报告。
