Okawa H, Nagasawa M, Morio T, Takase K, Tanaka K, Yata J, Dan K, Nomura T, Sakamaki H, Onozawa Y
Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Int J Hematol. 1992 Apr;55(2):165-71.
Between 1983-1988 bone marrow samples obtained from 195 peroxidase-negative leukemia patients were analyzed for their surface antigens. Thirteen of these patients (6.7%) had myelomonocytic-positive and lymphoid-negative antigens. These leukemic cells reacted with CD13 in eight patients, CD33 in seven, CD11 in six and CDw41 in two. In none of these patients did the leukemic cells react with CD1, CD2, CD3, CD4, CD5, CD8, CD10, CD19 or CD20. Leukemic cells from two patients were reactive with CD7. These leukemic cells demonstrated L2 morphology in 11 patients and L1 morphology in one patient. The leukemic cells from the final patient were diagnosed as those of leukemic transformation of myelodysplastic syndrome. Chromosomal abnormality was observed in approximately half of the patients examined (6/10). Cytochemical analysis revealed that the leukemic cells were negative for periodic acid Schiff stain but positive for acid phosphatase. The prognosis of these patients was markedly poor as compared to acute lymphocytic leukemia or typical peroxidase-positive nonlymphocytic leukemia. Complete remission was induced in only 30% of patients and duration of survival was short (4.7 months). This suggests that myelomonocytic antigen-positive peroxidase-negative acute leukemia is a distinct type of leukemia and may require more aggressive therapy to improve survival.
1983年至1988年间，对195例过氧化物酶阴性白血病患者的骨髓样本进行了表面抗原分析。其中13例患者（6.7%）具有髓单核细胞阳性和淋巴细胞阴性抗原。这些白血病细胞在8例患者中与CD13反应，7例与CD33反应，6例与CD11反应，2例与CDw41反应。在这些患者中，白血病细胞均未与CD1、CD2、CD3、CD4、CD5、CD8、CD10、CD19或CD20反应。2例患者的白血病细胞与CD7反应。这些白血病细胞在11例患者中表现为L2形态，1例患者表现为L1形态。最后1例患者的白血病细胞被诊断为骨髓增生异常综合征白血病转化型。在大约一半的受检患者（6/10）中观察到染色体异常。细胞化学分析显示，白血病细胞对过碘酸希夫染色呈阴性，但对酸性磷酸酶呈阳性。与急性淋巴细胞白血病或典型的过氧化物酶阳性非淋巴细胞白血病相比，这些患者的预后明显较差。仅30%的患者诱导出完全缓解，生存期较短（4.7个月）。这表明髓单核细胞抗原阳性过氧化物酶阴性急性白血病是一种独特的白血病类型，可能需要更积极的治疗来提高生存率。
