Buschard K, Pedersen C, Hansen S V, Hageman I, Aaen K, Bendtzen K
Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark.
Autoimmunity. 1992;14(2):101-4. doi: 10.3109/08916939209083127.
Fusidic acid and its sodium salt (fusidin) are anti-staphylococcal drugs. In vitro studies have shown that they prevent the lymphocyte co-stimulatory activities of the cytokines IL-1 and IL-6 in a manner similar to that of cyclosporin A, and prevent the inhibitory effect of IL-1 on glucose-induced insulin production. As IL-1 and IL-6 are thought to play a role in the pathogenesis of Type 1 diabetes, the aim of this study was to investigate whether fusidin could influence the disease incidence of the spontaneously diabetic BB rat model. Accordingly, a group of 50 BB rats receiving fusidin dissolved in their drinking water were compared to a control group of 55 rats over a period of 200 days. The incidence of diabetes was found to be 52% in the experimental group and 71% in the control group (P < 0.05). The degree of insulitis and the number of islets at histological examination were similar among the non-diabetic animals whereas the diabetic fusidin-treated animals showed a higher degree of islet preservation than the diabetic control rats. The results are highly indicative of an anti-diabetogenic effect of fusidin.
夫西地酸及其钠盐（梭链孢酸钠）是抗葡萄球菌药物。体外研究表明，它们以类似于环孢素A的方式抑制细胞因子IL-1和IL-6的淋巴细胞共刺激活性，并阻止IL-1对葡萄糖诱导的胰岛素分泌的抑制作用。由于IL-1和IL-6被认为在1型糖尿病的发病机制中起作用，本研究的目的是调查梭链孢酸钠是否会影响自发糖尿病BB大鼠模型的疾病发病率。因此，将一组50只饮用含梭链孢酸钠饮水的BB大鼠与一组55只大鼠的对照组在200天内进行比较。发现实验组的糖尿病发病率为52%，对照组为71%（P<0.05）。在非糖尿病动物中，组织学检查时的胰岛炎程度和胰岛数量相似，而用梭链孢酸钠治疗的糖尿病动物比糖尿病对照大鼠显示出更高程度的胰岛保存。结果强烈表明梭链孢酸钠具有抗糖尿病作用。
