Nicoletti F, Di Marco R, Morrone S, Zaccone P, Lembo D, Grasso S, Santoni A, Meroni P L, Bendtzen K
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Immunology. 1994 Feb;81(2):317-21.
Diabetes-prone (DP) BB rats spontaneously develop a hyperglycaemic condition which closely resembles human insulin-dependent diabetes mellitus (IDDM), both in terms of clinical and histological features. The incidence of IDDM was significantly reduced when these animals were treated with 2 or 4 mg fusidic acid (FA)/day i.m. from day 30 to day 120 of age. In addition, the mean insulitis score was significantly diminished in the animals treated with FA compared to both vehicle-treated and untreated controls. Finally, 2 mg/day of FA i.m. prevented cell proliferation and interferon-gamma secretion from peripheral blood mononuclear cells upon ex vivo stimulation with concanavalin A. The capacity of FA to substantially reduce the incidence of autoimmune diabetes in a well-known animal model of human IDDM supports previous observations regarding the immunosuppressive properties of FA and its potential use in the treatment of human autoimmune diabetes.
糖尿病易感性（DP）BB大鼠会自发出现高血糖状况，在临床和组织学特征方面都与人类胰岛素依赖型糖尿病（IDDM）极为相似。从30日龄至120日龄，每天肌肉注射2毫克或4毫克夫西地酸（FA）对这些动物进行治疗时，IDDM的发病率显著降低。此外，与溶剂处理组和未处理的对照组相比，接受FA治疗的动物的平均胰岛炎评分显著降低。最后，每天2毫克肌肉注射FA可在体外使用伴刀豆球蛋白A刺激时阻止外周血单核细胞的细胞增殖和γ干扰素分泌。在一个著名的人类IDDM动物模型中，FA大幅降低自身免疫性糖尿病发病率的能力支持了之前关于FA免疫抑制特性及其在治疗人类自身免疫性糖尿病方面潜在用途的观察结果。
