Peachey N S, Arakawa K, Alexander K R, Marchese A L
Hines VA Hospital, IL 60141.
Vision Res. 1992 Nov;32(11):2049-53. doi: 10.1016/0042-6989(92)90066-r.
Changes in the response characteristics of the human cone electroretinogram (ERG) during light and dark adaptation were studied in two visually normal subjects. Cone ERG responses were isolated under all adaptation conditions through the use of 31 Hz flicker. To determine the time-course of changes in the cone ERG during adaptation, responses to stimuli of constant luminance were measured repeatedly during 15 min of exposure to an adapting field of 2.0 log cd/m2 and during 30 min of dark adaptation following adapting field termination. In addition, luminance-response functions were obtained before and immediately after adapting field onset, as well as before and immediately after adapting field termination. The results indicate that the human cone ERG is influenced by two major processes. One process has a relatively rapid time-course and serves to reposition the luminance-response function along the luminance axis following changes in ambient light levels. The second process, which has a slow time-course, scales response amplitudes during light and dark adaptation by the same proportion at all stimulus luminances. The results provide a framework for predicting the manner in which the cone ERG will change with alterations in the state of retinal adaptation.
在两名视力正常的受试者中研究了人类视锥细胞视网膜电图（ERG）在明适应和暗适应过程中反应特性的变化。通过使用31Hz闪烁光，在所有适应条件下分离出视锥细胞ERG反应。为了确定适应过程中视锥细胞ERG变化的时间进程，在暴露于2.0 log cd/m2的适应场15分钟期间以及适应场终止后的30分钟暗适应期间，反复测量对恒定亮度刺激的反应。此外，在适应场开始前和刚结束后以及适应场终止前和刚结束后，获取亮度-反应函数。结果表明，人类视锥细胞ERG受两个主要过程的影响。一个过程具有相对较快的时间进程，在环境光水平变化后，用于沿亮度轴重新定位亮度-反应函数。第二个过程时间进程较慢，在明适应和暗适应期间，在所有刺激亮度下按相同比例缩放反应幅度。这些结果为预测视锥细胞ERG随视网膜适应状态改变而变化的方式提供了一个框架。
