Paliĭ G K, Mrug V M
Antibiot Khimioter. 1992 Dec;37(12):36-8.
The development of resistance of collection and freshly isolated S. aureus and C. albicans strains to the antiseptic decamethoxim and an original diarylcyclohexane derivative was studied comparatively in vitro. It was shown that the rate of the resistance development was low. After 20 subcultures in the presence of increasing concentrations of decamethoxin, its sensitivity of S. aureus and C. albicans decreased 16-32 and 16-fold respectively. After 20 subcultures in the presence of increasing doses of the diarylcyclohexane derivative, its sensitivity S. aureus and C. albicans decreased 4- and 4-8-fold, respectively. It was found that in the hospital strains of S. aureus and C. albicans, the antibiotic resistance and sensitivity to decamethoxin and the diarylcyclohexane remained high, which indicated that there was no cross resistance to these compounds in the strains studied.
在体外比较研究了收集的以及新鲜分离的金黄色葡萄球菌和白色念珠菌菌株对防腐剂十甲季铵肟和一种新型二芳基环己烷衍生物的耐药性发展情况。结果表明，耐药性发展速率较低。在十甲季铵浓度不断增加的情况下传代培养20次后，金黄色葡萄球菌和白色念珠菌对其敏感性分别降低了16至32倍和16倍。在二芳基环己烷衍生物剂量不断增加的情况下传代培养20次后，金黄色葡萄球菌和白色念珠菌对其敏感性分别降低了4倍和4至8倍。研究发现，在医院的金黄色葡萄球菌和白色念珠菌菌株中，对十甲季铵肟和二芳基环己烷的抗生素耐药性及敏感性仍然很高，这表明在所研究的菌株中不存在对这些化合物的交叉耐药性。
