Paliĭ G K, Ivanova S A
Antibiot Med Biotekhnol. 1986 Mar;31(3):218-20.
Sensitivity of 50 Candida fungus strains isolated from patients with chronic intestine diseases was studied with respect to amphotericin B, levorin, enteroseptol, intestopan and decamethoxin. The rate of forming resistant variants of the strains with respect to decamethoxin and development of their cross resistance to levorin was estimated. It was shown that decamethoxin was the most active antifungal drug among the drugs tested. Estimation of sensitivity of the Candida strains to enteroseptol and intestopan revealed that the fungicidal concentration of enteroseptol for 78 per cent of the strains ranged within 3.9-7.8 micrograms/ml. It was demonstrated that development of resistance to decamethoxin in the strains of Candida albicans was slow and did not reach high levels. No cross resistance between decamethoxin and levorin was detected.
对从慢性肠道疾病患者中分离出的50株念珠菌真菌菌株，针对两性霉素B、制霉菌素、氯碘羟喹、肠得安和地卡米松进行了敏感性研究。评估了这些菌株对地卡米松形成耐药变体的比率及其对制霉菌素交叉耐药性的发展情况。结果表明，在所测试的药物中，地卡米松是最具活性的抗真菌药物。对念珠菌菌株对氯碘羟喹和肠得安的敏感性评估显示，78%的菌株对氯碘羟喹的杀菌浓度范围在3.9 - 7.8微克/毫升之间。结果表明，白色念珠菌菌株对地卡米松的耐药性发展缓慢，且未达到高水平。未检测到地卡米松和制霉菌素之间的交叉耐药性。
