Krishnamoorthy K, Sabesan S, Panicker K N, Prathiba J
Vectrol Control Research Centre, Pondicherry, India.
Natl Med J India. 1992 May-Jun;5(3):104-7.
Diethylcarbamazine is effective for the treatment of brugian filaria carriers. However, the 12-day course with a daily dose of 6 mg per kg body weight is rarely completed. The World Health Organization has indicated the need for better regimes to control filariasis.
We evaluated the long term effects of three different dosage regimes of diethylcarbamazine--6, 9 and 12 mg per kg body weight--to a total of 72 mg on 93 microfilaria carriers of Brugia malayi.
All cases treated with the 6 mg daily dose showed complete clearance of microfilaria immediately after the treatment. However, at the 9 and 12 mg daily doses only 91% and 85% of cases respectively showed complete clearance. There was a close association between the daily dose and the proportion of cases developing side-effects. The mean initial microfilaria counts were significantly higher in those who had side-effects than in those who did not. An 11-month follow up showed that with the 6 mg daily dose the recurrence rate of microfilaraemia was 29% while with the 12 mg daily dose it was 67%. Four per cent of patients on a daily dose of 6 and 9 mg discontinued treatment while 21% of those on the 12 mg daily dose did so.
The 6 mg daily dose of diethylcarbamazine was the most effective and best accepted regime.
乙胺嗪对马来布鲁线虫携带者的治疗有效。然而，每日剂量为每千克体重6毫克、疗程为12天的治疗方案很少能完成。世界卫生组织指出需要更好的方案来控制丝虫病。
我们评估了乙胺嗪三种不同剂量方案（每千克体重6毫克、9毫克和12毫克，总量达72毫克）对93名马来布鲁线虫微丝蚴携带者的长期影响。
所有接受每日6毫克剂量治疗的病例在治疗后立即显示微丝蚴完全清除。然而，每日9毫克和12毫克剂量时，分别只有91%和85%的病例显示完全清除。每日剂量与出现副作用的病例比例之间存在密切关联。出现副作用者的初始微丝蚴平均计数显著高于未出现副作用者。11个月的随访显示，每日6毫克剂量时微丝蚴血症复发率为29%，而每日12毫克剂量时为67%。每日剂量为6毫克和9毫克的患者中有4%中断治疗，而每日剂量为12毫克的患者中有21%中断治疗。
乙胺嗪每日6毫克剂量是最有效且最易接受的方案。
