婴儿猝死综合征中脑干和脑脊液中的β-内啡肽与神经降压素

Beta-endorphin and neurotensin in brainstem and cerebrospinal fluid in the sudden infant death syndrome.

作者信息

Coquerel A, Buser M, Tayot J, Pfaff F, Matray F, Proust B

机构信息

Centre Hospitalier Universitaire, Rouen, France.

出版信息

Neurochem Int. 1992 Jan;20(1):97-102. doi: 10.1016/0197-0186(92)90131-a.

DOI:10.1016/0197-0186(92)90131-a

PMID:1304324

Abstract

Beta-endorphin (BE) and neurotensin (NT) are two neuropeptides which induce apneas. In infants who died of Sudden Infant Death Syndrome (SIDS) we measured, in brainstem and CSF, BE and NT by IRMA and RIA respectively. BE and NT levels are compared to same aged infant and adult controls. CSF BE level was significantly higher in SIDS than in the two control groups (86 +/- 14 vs 33 +/- 13 and 16 +/- 5 pmol/l). In 6 SIDS victims NT and BE were assayed in 5 brainstem sections, each of them divided in median, intermediate and lateral parts. We found high levels of BE in every fragment (3-11 pmol/mg protein) while NT elevated values were restricted to the mesencephalic regions (1.4-12 pmol/mg), the medial pons (6 pmol/mg) and the intermediate parts of the medulla (including the olive: 1.3-1.6 pmol/mg). These results support the hypothesis that NT and/or BE could induce or participate to the fetal issue of SIDS.

摘要

β-内啡肽（BE）和神经降压素（NT）是两种可诱发呼吸暂停的神经肽。在死于婴儿猝死综合征（SIDS）的婴儿中，我们分别通过免疫放射分析（IRMA）和放射免疫分析（RIA）测定了脑干和脑脊液中的BE和NT。将BE和NT水平与同龄婴儿及成人对照组进行比较。SIDS患儿脑脊液中的BE水平显著高于两个对照组（86±14 vs 33±13和16±5 pmol/L）。在6例SIDS受害者中，对5个脑干切片中的NT和BE进行了检测，每个切片又分为中间、中间外侧和外侧部分。我们发现每个片段中的BE水平都很高（3 - 11 pmol/mg蛋白质），而NT升高的值仅限于中脑区域（1.4 - 12 pmol/mg）、脑桥内侧（6 pmol/mg）和延髓中间部分（包括橄榄体：1.3 - 1.6 pmol/mg）。这些结果支持了NT和/或BE可能诱发或参与SIDS胎儿问题的假说。