阿尔茨海默病中神经节苷脂的皮质分布
Cortical distribution of gangliosides in Alzheimer's disease.
作者信息
Kracun I, Kalanj S, Talan-Hranilovic J, Cosovic C
机构信息
Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, Croatia.
出版信息
Neurochem Int. 1992 Apr;20(3):433-8. doi: 10.1016/0197-0186(92)90058-y.
In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.
在阿尔茨海默病中，发现所有神经节系列神经节苷脂（GM1、GD1a、GD1b和GT1b）在颞叶和额叶皮质以及Meynert基底核中均减少。此外，在阿尔茨海默病中，额叶和顶叶皮质中的简单神经节苷脂（GM2、GM3）升高，这可能与神经节苷脂的溶酶体降解加速和/或神经元死亡期间发生的星形胶质细胞增生有关。
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