[马桑内酯点燃大鼠海马脑片CA1区双脉冲抑制现象的观察]

[Observation of paired-pulse depression in CA1 region of hippocampal slices from coriaria lactone-kindled rats].

作者信息

Guo L, Chai H, Xie Y, Liu X

出版信息

Hua Xi Yi Ke Da Xue Xue Bao. 1992 Sep;23(4):399-402.

Abstract

Paired-pulse depression (PPD) technique was used to investigate the potency of recurrent synaptic inhibition mediated by GABA in area CA1 of 54 hippocampal slices from coriaria lactone (CL)-kindled and control rats. When paired stimuli were sent to the axon of CA1 pyramidal cell and Schaffer collaterals, the effect of population spike PPD lasted about 40-60ms; no significant change was observed on PPD potency between kindled and control groups (P = 0.06, 2-way ANOVA). The results indicate that the GABA-ergic synaptic inhibition seemed not to play a key role in the maintenance of the chemical kindling induced by CL.

摘要

采用双脉冲抑制（PPD）技术，研究了马桑内酯（CL）点燃大鼠和对照大鼠54个海马脑片CA1区中由γ-氨基丁酸（GABA）介导的反复性突触抑制的效能。当向CA1锥体细胞轴突和Schaffer侧支发送成对刺激时，群体峰电位PPD的效应持续约40 - 60毫秒；点燃组和对照组之间的PPD效能未观察到显著变化（P = 0.06，双向方差分析）。结果表明，GABA能突触抑制似乎在CL诱导的化学性点燃维持中不发挥关键作用。