Khallaayoune K, Stromberg B E
Department de Parasitologie et Maladies Parasitaires, Institut Agronomique et Veterinaire Hassan II, Rabat-Instituts, Morocco.
Trop Anim Health Prod. 1992 Aug;24(3):129-34. doi: 10.1007/BF02359601.
This study evaluated the production advantages of the strategic anthelmintic treatment of both lambs and ewes in an area endemic for gastro-intestinal nematodes, lungworms and liver flukes. The liver fluke infections were generally chronic. The lambs were treated with albendazole (SmithKline Beecham), fenbendazole (Hoechst Roussel) or a vitamin supplement and their weight gains were followed over the next 7 months. The control group, which received a vitamin supplement only, gained 6.67 kg from July to January. The group that received fenbendazole, an anthelmintic with no activity against liver flukes, gained 10.42 kg over the study period. The third group which received albendazole, an anthelmintic with efficacy against liver flukes, gained 13.07 kg over the same period. Lamb deaths apparently due to liver flukes were 12, 4, and zero for the control, fenbendazole and albendazole groups, respectively. Similar advantages were observed in the ewes. Deaths were 16, 8, and zero in the control, fenbendazole and albendazole groups, respectively. The lambing rate in the control group was significantly lower than that in either of the 2 treated groups. The number of services per conception was significantly lower in the albendazole treated group than that in either of the other groups. These studies demonstrated the advantages of anthelmintic treatment in sheep in a helminth endemic area. While removing gastro-intestinal nematodes and lungworms improved production, the additional removal of liver flukes enhanced production gains as well as reducing deaths.
本研究评估了在一个胃肠道线虫、肺线虫和肝吸虫流行地区对羔羊和母羊进行战略性驱虫治疗的生产优势。肝吸虫感染通常为慢性感染。给羔羊使用阿苯达唑（史克必成公司生产）、芬苯达唑（赫斯特·罗塞尔公司生产）或一种维生素补充剂进行治疗，并在接下来的7个月内跟踪它们的体重增加情况。仅接受维生素补充剂的对照组在7月至1月期间体重增加了6.67千克。接受芬苯达唑（一种对肝吸虫无活性的驱虫药）治疗的组在研究期间体重增加了10.42千克。接受阿苯达唑（一种对肝吸虫有效的驱虫药）治疗的第三组在同一时期体重增加了13.07千克。对照组、芬苯达唑组和阿苯达唑组中，明显因肝吸虫导致的羔羊死亡数分别为12头（对照组）、4头（芬苯达唑组）和0头（阿苯达唑组）。在母羊中也观察到了类似的优势。对照组、芬苯达唑组和阿苯达唑组的死亡数分别为16头、8头和0头。对照组的产羔率显著低于两个治疗组中的任何一组。阿苯达唑治疗组每受孕所需的配种次数显著低于其他任何一组。这些研究证明了在蠕虫流行地区对绵羊进行驱虫治疗的优势。去除胃肠道线虫和肺线虫可提高产量，而额外去除肝吸虫不仅能增加产量收益，还能减少死亡。
