Cooper N A, Rolfe P F, Searson J E, Dawson K L
Bayer Australia Limited, Pymble, New South Wales.
Aust Vet J. 1996 Sep;74(3):221-4. doi: 10.1111/j.1751-0813.1996.tb15408.x.
To investigate the relative efficacy and safety of the anthelmintic naphthalophos in sheep, either given alone or in combination with benzimidazole (fenbendazole and albendazole) or levamisole anthelmintics.
A parasitological study using faecal egg count reduction tests, a validating slaughter trial and field safety trials.
Faecal egg count reduction tests were carried out on 13 farms. Naphthalophos and combinations of naphthalophos with levamisole and fenbendazole were included in the drench tests. On one property a controlled efficacy study was carried out to validate faecal egg count reduction test findings. In this trial, sheep were slaughtered 10 days after treatment and the remaining parasites recovered from the gastro-intestinal tract. Safety trials were carried out on eight farms where approximately 50,000 sheep were treated with naphthalophos and albendazole that were tank mixed in the backpack.
The efficacy of naphthalophos alone in faecal egg count reduction tests ranged from 59 to 98% with one test showing > or = 95% reduction. The efficacy of naphthalophos and levamisole ranged from 74 to 100%, with 5 farms showing > or = 95% reduction. The efficacy of naphthalophos and fenbendazole ranged between 88 and 100% with > or = 95% reduction achieved on 10 farms. The controlled efficacy study showed a good correlation between the faecal egg count reduction tests and numbers of parasites recovered, except for Nematodirus where the faecal egg count reduction test overestimated efficacy. The mortality rate in the safety trials was 0.05%, with most fatalities occurring on one farm.
The combination of naphthalophos and fenbendazole was more effective than a combination of naphthalophos and levamisole, and will provide a sufficiently safe drench rotation option.
研究驱虫药萘肽磷单独使用，或与苯并咪唑类（芬苯达唑和阿苯达唑）或左旋咪唑类驱虫药联合使用时，对绵羊的相对疗效和安全性。
一项采用粪便虫卵计数减少试验、验证性屠宰试验和田间安全性试验的寄生虫学研究。
在13个农场进行粪便虫卵计数减少试验。驱虫试验中包括萘肽磷以及萘肽磷与左旋咪唑和芬苯达唑的组合。在一个养殖场进行了对照疗效研究，以验证粪便虫卵计数减少试验的结果。在此试验中，绵羊在治疗后10天被屠宰，并从胃肠道中回收剩余的寄生虫。在8个农场进行了安全性试验，约50000只绵羊接受了背包式药箱中混合的萘肽磷和阿苯达唑治疗。
在粪便虫卵计数减少试验中，单独使用萘肽磷的疗效为59%至98%，其中一项试验显示减少率≥95%。萘肽磷与左旋咪唑联合使用的疗效为74%至100%，5个农场显示减少率≥95%。萘肽磷与芬苯达唑联合使用的疗效在88%至100%之间，10个农场的减少率≥95%。对照疗效研究表明，除了细颈线虫属，粪便虫卵计数减少试验与回收的寄生虫数量之间具有良好的相关性，在细颈线虫属中，粪便虫卵计数减少试验高估了疗效。安全性试验中的死亡率为0.05%，大多数死亡发生在一个农场。
萘肽磷与芬苯达唑的组合比萘肽磷与左旋咪唑的组合更有效，并且将提供一种足够安全的驱虫药轮换选择。
