Chłopkiewicz B, Marczewska J, Ejchart A, Anuszewska E, Koziorowska J
Drug Institute, Warsaw, Poland.
Drugs Exp Clin Res. 1992;18 Suppl:31-4.
Evaluation of mutagenic and genotoxic properties of Ukrain was on the basis of the Ames and micronucleus tests. Ukrain was investigated for its ability to induce morphological transformation of embryonic cells of the Syrian hamster. Under the experimental condition used in this study, Ukrain was found to be non-mutagenic and non-genotoxic, and furthermore did not induce morphological cell transformation.
基于艾姆斯试验和微核试验对乌头碱的致突变和遗传毒性特性进行了评估。研究了乌头碱诱导叙利亚仓鼠胚胎细胞形态转化的能力。在本研究使用的实验条件下,发现乌头碱无致突变性和遗传毒性,而且不会诱导细胞形态转化。