托非索泮——致突变和遗传毒性特性评估。
Tofisopam--evaluation of mutagenic and genotoxic properties.
作者信息
Chłopkiewicz B, Ejchart A, Anuszewska E
机构信息
Drug Institute, 30/34 Chełmska Str., 00-725 Warsaw, Poland.
出版信息
Acta Pol Pharm. 2001 Jan-Feb;58(1):31-4.
PMID:11370285
Abstract
The mutagenic properties of tofisopam, the member of the 2,3-benzodiazepine family, were evaluated on the basis of Ames test with Salmonella typhimurium TA1537, TA97, TA98, TA100 and TA102 strains. The genotoxic properties of tofisopam were estimated on L929 cell line with the cytokinesis-block technique. Under the experimental conditions, no mutagenic activity of tofisopam in tester bacteria strains was found, and no genotoxic activity was observed.
摘要
基于对鼠伤寒沙门氏菌TA1537、TA97、TA98、TA100和TA102菌株进行的艾姆斯试验，评估了2,3-苯二氮䓬家族成员托非索泮的致突变特性。采用胞质分裂阻断技术，在L929细胞系上评估了托非索泮的遗传毒性特性。在实验条件下，未发现托非索泮在受试菌株中有致突变活性，也未观察到遗传毒性活性。
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