Ostapenko V V, Waĭnson A A
Fiziol Zh (1978). 1992 Sep-Oct;38(5):67-9.
The radioprotective action of hypoxia in local irradiation of kidneys was studied. The experiments were carried out on hybrid mice (CBA x C57Bl) exposed to local X-ray irradiation through a lead diaphragm matched to the kidneys. In the experimental group the animals breathed in gaseous mixture with 8% of oxygen prior to and during irradiation. 20-36 weeks after irradiation the functions of glomerular and juxtaglomerular systems, as well as mass of native and dried kidneys were studied in the animals. It is shown that hypoxia efficiently protects kidneys against irradiation and permits increasing the supplied dose of radiation at least by 25%. High-efficient protection is retained when passing from single to fractionated irradiation.
研究了缺氧在肾脏局部照射中的辐射防护作用。实验在通过与肾脏匹配的铅制隔板进行局部X射线照射的杂种小鼠（CBA×C57Bl）上进行。在实验组中，动物在照射前和照射期间吸入含8%氧气的气体混合物。照射后20 - 36周，研究了动物肾小球和近球系统的功能以及正常和干燥肾脏的质量。结果表明，缺氧能有效保护肾脏免受辐射，并使辐射剂量至少增加25%。从单次照射过渡到分次照射时，仍能保持高效的防护作用。
